Fc-fusion is an important part of half-life extension methods. At present, many of the existing half-life extension drugs are achieved by Fc-fusion. As an industry-leading CRO company, Creative Biolabs has an optimized technology platform offering comprehensive one-stop Fc-Fusion-Based Half-Life Extension services.
Screening and discovering drugs for the treatment of infectious diseases is a crucial task, forming the core of combating infectious diseases and ensuring public health safety. Infectious diseases such as influenza, AIDS, and novel coronaviruses have the characteristic of rapid transmission, posing a significant threat to public health. Learn more: antiviral medications are a common treatment for
Monkeypox Virus Real Time PCR Kit is a real-time PCR technique for detecting MPXV DNA in vesicles or pustules, nasopharyngeal swab, oropharyngeal swab, serum, whole blood. This product is furnished for research use only. Not for diagnostic or therapeutic use. Learn more: monkeypox rt pcr kit
As a world-leading service provider of antibody development and engineering, Creative Biolabs has combined artificial intelligence, big data, and machine learning to generate a novel artificial intelligence (AI)-powered computational antibody drug discovery platform to predict antibody-antigen binding and provide antibody drug candidates. Learn more: AI drug discovery platform
In reality, small chemical compounds of 700-1500 Da are not appropriate immunogens. But, when attached to macromolecules, they usually become great immunogenic agents. These small molecules are referred to as a hapten and macromolecules conferring hapten immunogenic are referred to as a carrier. The hapten can be thought of as an exogenous epitope linked to the carrier. Learn more: TCs Hapten
Complement is an important defense line of our immune system. With decades of experience, Creative Biolabs has successfully developed versatile drug discovery platforms, from which, we can provide our worldwide clients with the most diverse portfolio of standard or custom therapeutic antibodies development services. In addition, we can also offer high-quality products and valuable suggestions to promote your specific projects. Learn more: CD59 complement
As the monkeypox virus has been spreading worldwide, causing a series of human health problems and even death, it becomes an important international public health issue. It is of vital importance to develop and manufacture high-efficient and safe vaccines for monkeypox. As a professional pre-clinical vaccine development and production server, Creative Biolabs has been engaged in the vaccine industry for over a decade. Learn more: monkeypox vaccine discovery
Creative Biolabs offers a series of AI-based antibody screening services based on the prediction of antibody-antigen binding. We offer a unique way to find rare antibody clusters and get more candidate antibody sequences by augmenting our data-driven AI screening services. Learn more: antibody screening AI models
Fluorescence in situ hybridization (FISH) is a technique that allows the visualization of specific nucleic acid sequences within a cellular preparation. It has potential applications in in vitro diagnostics (IVD), gene expression analysis, and cancer surveillance. With many years of rich experience and in-depth knowledge, Creative Biolabs provides high-quality FISH services to help the pipeline of IVD development. We have a well-established standard operating procedure that allows efficient optimization of labeling a variety of fluorescent probes, sample preparation, hybridization conditions, and imaging analysis.
Since the commercial development of therapeutic monoclonal antibodies commenced in the early 1980s, the monoclonal antibodies have grown to become the most successful class of biotech drugs for the diagnosis and treatment against various diseases and infections. Learn more: IgM Antibody Services
Neurotoxicity screening is a relatively new field, and its progress is limited by factors that complicate neurotoxicology assessment. It has been proved that episodes of neurotoxic illness can be induced by chemicals, such as Lucel-7. According to the analysis of structure-activity relationships (SARs), only a small fraction of neurotoxicants can be identified. In this case, a series of in vivo and in vitro tests are necessary. Compared to other organ systems, the nervous system exhibits a more complex cell structure and chemical heterogeneity. To examine all aspects of the human nervous system as comprehensively as possible, it is necessary to perform neurotoxicity tests using multiple cell types. Learn more: neurotoxicity study
The human brain is a complex organ composed of a variety of cell types and signaling pathways. Since mature neurons do not undergo cell division again, it is necessary to establish immortalized secondary cell lines derived from neuronal tumors, that is, to acquire the ability to generate in vitro cultures of neuronal cells. The established molecular tools and stem cell line models can mimic the physiology of the brain for a better understanding of neurological diseases and treatment strategies. Based on our excellent primary cells, stem cells, and other cell line models, it would be possible to create in vitro culture systems that mimic in vivo environments. Learn more: nsc 34 cell line
Next-generation probiotics (NGPs) have been widely investigated as a treatment modality for gastrointestinal disorders. With extensive expertise in the human probiotic field, Creative Biolabs is committed to deepening our understanding of the role of microbiota in human health aided by our next-generation sequencing and analytic tools, experimental technologies, and animal models. We have explored a live biotherapeutics discovery platform for NGP development, pre-clinical studies, and cGMP manufacturing to address different demands for pre-clinical, clinical, and commercial applications. Learn more: live biotherapeutics drug discovery services for gastrointestinal disorders
Creative Biolabs has dedicated to lipid-based drug delivery system research for over a decade of years. The lipid-core micelles system including PC/bile salt mixed micelles and phospholipid micelles is just one class of our well-developed delivery systems. Based on profound expertise and universal technical platforms, we provide a wide range of lipid-core micelles drug delivery services comprising pre-made and specific customized formulations, developments, applications, and related services to global clients.
Scientists in Creative Biolabs are pleased to introduce our state-of-the-art proprietary technology of hybridoma generation against autologous proteins. In general, self-antigens or homologous proteins with conserved domains among species had always been ‘‘problematic’’ antigens for hybridoma generation due to poor or no immune response. The immunization of ‘‘knock-out’’ mice was an effective way to overcome the problem of inter-species sequence similarity in antibody production. Learn more: Hybridoma Generation in Gene Inactivated Mice
Recombinant human monoclonal antibody expressed in CHO binding to human Hepatitis B virus. Tuvirumab is a human monoclonal antibody for the treatment of patients with chronic hepatitis B.
Alzheimer's disease (AD) is the most common form of dementia, a complex neurodegenerative brain disorder characterized by the progressive impairment of cognitive functions, particularly memory, thinking, language, mood, and behavioral issues. Learn more: Ad research Reagents
This program aims at developing therapeutic monoclonal antibodies against the target – Glucocorticoid-induced TNFR-related protein (GITR).
GITR is a promising target for immunotherapy due to its ability to promote T-cell effector (Teff) functions and hamper the regulation of T-cell (Treg) suppression. Multiple studies have shown that agonist anti-GITR antibodies are very potent in their anti-tumor activity. For this reason, the highlight of this program is to use GITR as a potential novel therapeutic target in the field of immune-oncology. Learn more: Next-IO™ Anti-GITR Monoclonal Antibody Program
Although chimeric antigen receptor (CAR) engineered T (CAR-T) cells have achieved significant success in the treatment of hematological malignancies, the interest in CAR-transduced NK cells (CAR-NK) has rapidly increased due to the limited number of T cells. Compared with CAR-T cells, CAR-NK cells have many advantages, such as the safety of clinical use, the mechanism of recognizing cancer cells, and the abundance in clinical samples. To avoid these obstacles, researchers are turning to natural killer (NK) cells to expand the application of CAR-directed therapy in patients with B-cell malignancies. As a leading cell therapeutics provider, Creative Biolabs supplies high-quality CellRapeutics™ CAR-NK vector construction service tailored to your special needs.
Empowered by unrivaled expertise and advances in single-cell approaches, Creative Biolabs has developed integrated single cell omics solutions to study differences between cell types and subpopulations, at single-cell level of genome, transcriptome, epigenome, and proteome. We are dedicated to discovering the differences at single-cell level, facilitating your projects in diverse areas of biology and disease, such as immunology, oncology, microbiome, development, etc. Learn more: Single Cell Omics services