Scientists in Creative Biolabs are pleased to introduce our state-of-the-art proprietary technology of hybridoma generation against autologous proteins. In general, self-antigens or homologous proteins with conserved domains among species had always been ‘‘problematic’’ antigens for hybridoma generation due to poor or no immune response. The immunization of ‘‘knock-out’’ mice was an effective way to overcome the problem of inter-species sequence similarity in antibody production. Learn more: Hybridoma Generation in Gene Inactivated Mice